Genetic influences on behavioral and neuroendocrine responses to predator-odor stress in rats.
Identifieur interne : 000789 ( Main/Exploration ); précédent : 000788; suivant : 000790Genetic influences on behavioral and neuroendocrine responses to predator-odor stress in rats.
Auteurs : Leandro Franco Vendruscolo [France] ; Janaína Carrinho Muniz Vendruscolo ; Elena Terenina-Rigaldie ; Frantz Raba ; André Ramos ; Reinaldo Naoto Takahashi ; Pierre MormèdeSource :
- Neuroscience letters [ 0304-3940 ] ; 2006.
English descriptors
- KwdEn :
- Animals, Behavior, Animal (physiology), Corticosterone (blood), Feces (chemistry), Female, Foxes (physiology), Male, Microsatellite Repeats (genetics), Neurosecretory Systems (physiopathology), Nociceptors (drug effects), Odorants, Pain Measurement (drug effects), Predatory Behavior (physiology), Rats, Rats, Inbred Lew, Rats, Inbred SHR, Stress, Psychological (genetics), Stress, Psychological (physiopathology), Stress, Psychological (psychology), Thiazoles (pharmacology).
- MESH :
- chemical , blood : Corticosterone.
- chemistry : Feces.
- drug effects : Nociceptors, Pain Measurement.
- genetics : Microsatellite Repeats, Stress, Psychological.
- chemical , pharmacology : Thiazoles.
- physiology : Behavior, Animal, Foxes, Predatory Behavior.
- physiopathology : Neurosecretory Systems, Stress, Psychological.
- psychology : Stress, Psychological.
- Animals, Female, Male, Odorants, Rats, Rats, Inbred Lew, Rats, Inbred SHR.
Abstract
The exposure of animals to a variety of stressful events can induce behavioral and physiological responses, which can be modulated by anxiety levels. It is well recognized that genetic factors play a substantial role in both anxiety and stress reactivity. The present study examined the effect of exposure to 2,4,5-trimethylthiazoline (TMT), a component of fox feces, on nociception and corticosterone levels in Lewis (LEW) and Spontaneously Hypertensive (SHR) inbred rat strains (which display genetic differences in anxiety models such as the elevated plus-maze and open-field). The influence of two quantitative trait loci (QTL), named Ofil1 and Ofil2, which are known to affect emotionality in LEW versus SHR intercrosses on the responses to TMT was also investigated. LEW and SHR rats of both sexes displayed similar levels of behavioral and neuroendocrine responses after TMT exposure. As expected, TMT odor stress produced analgesia and enhanced corticosterone levels. Ofil1 on chromosome 4 affected stress-induced analgesia in males only. Ofil2 on chromosome 7 had no effect. The results suggest that behaviors measured in classical models of generalized anxiety and reactivity to stress produced by predator odors can be genetically dissociated. Finding a locus with an effect on the behavioral responses to stress represents the starting point in the search for genes responsible for stress-related traits.
DOI: 10.1016/j.neulet.2006.07.026
PubMed: 17052845
Affiliations:
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Le document en format XML
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Muniz" sort="Vendruscolo, Janaina Carrinho Muniz" uniqKey="Vendruscolo J" first="Janaína Carrinho Muniz" last="Vendruscolo">Janaína Carrinho Muniz Vendruscolo</name></author><author><name sortKey="Terenina Rigaldie, Elena" sort="Terenina Rigaldie, Elena" uniqKey="Terenina Rigaldie E" first="Elena" last="Terenina-Rigaldie">Elena Terenina-Rigaldie</name></author><author><name sortKey="Raba, Frantz" sort="Raba, Frantz" uniqKey="Raba F" first="Frantz" last="Raba">Frantz Raba</name></author><author><name sortKey="Ramos, Andre" sort="Ramos, Andre" uniqKey="Ramos A" first="André" last="Ramos">André Ramos</name></author><author><name sortKey="Takahashi, Reinaldo Naoto" sort="Takahashi, Reinaldo Naoto" uniqKey="Takahashi R" first="Reinaldo Naoto" last="Takahashi">Reinaldo Naoto Takahashi</name></author><author><name sortKey="Mormede, Pierre" sort="Mormede, Pierre" uniqKey="Mormede P" first="Pierre" last="Mormède">Pierre Mormède</name></author></analytic><series><title level="j">Neuroscience 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It is well recognized that genetic factors play a substantial role in both anxiety and stress reactivity. The present study examined the effect of exposure to 2,4,5-trimethylthiazoline (TMT), a component of fox feces, on nociception and corticosterone levels in Lewis (LEW) and Spontaneously Hypertensive (SHR) inbred rat strains (which display genetic differences in anxiety models such as the elevated plus-maze and open-field). The influence of two quantitative trait loci (QTL), named Ofil1 and Ofil2, which are known to affect emotionality in LEW versus SHR intercrosses on the responses to TMT was also investigated. LEW and SHR rats of both sexes displayed similar levels of behavioral and neuroendocrine responses after TMT exposure. As expected, TMT odor stress produced analgesia and enhanced corticosterone levels. Ofil1 on chromosome 4 affected stress-induced analgesia in males only. Ofil2 on chromosome 7 had no effect. The results suggest that behaviors measured in classical models of generalized anxiety and reactivity to stress produced by predator odors can be genetically dissociated. Finding a locus with an effect on the behavioral responses to stress represents the starting point in the search for genes responsible for stress-related traits.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li></region><settlement><li>Bordeaux</li></settlement></list><tree><noCountry><name sortKey="Mormede, Pierre" sort="Mormede, Pierre" uniqKey="Mormede P" first="Pierre" last="Mormède">Pierre Mormède</name><name sortKey="Raba, Frantz" sort="Raba, Frantz" uniqKey="Raba F" first="Frantz" last="Raba">Frantz Raba</name><name sortKey="Ramos, Andre" sort="Ramos, Andre" uniqKey="Ramos A" first="André" last="Ramos">André Ramos</name><name sortKey="Takahashi, Reinaldo Naoto" sort="Takahashi, Reinaldo Naoto" uniqKey="Takahashi R" first="Reinaldo Naoto" last="Takahashi">Reinaldo Naoto Takahashi</name><name sortKey="Terenina Rigaldie, Elena" sort="Terenina Rigaldie, Elena" uniqKey="Terenina Rigaldie E" first="Elena" last="Terenina-Rigaldie">Elena Terenina-Rigaldie</name><name sortKey="Vendruscolo, Janaina Carrinho Muniz" sort="Vendruscolo, Janaina Carrinho Muniz" uniqKey="Vendruscolo J" first="Janaína Carrinho Muniz" last="Vendruscolo">Janaína Carrinho Muniz Vendruscolo</name></noCountry><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Vendruscolo, Leandro Franco" sort="Vendruscolo, Leandro Franco" uniqKey="Vendruscolo L" first="Leandro Franco" last="Vendruscolo">Leandro Franco Vendruscolo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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